Nanoparticles containing extracellular matrix for drug delivery

US11491115B2 · kind B2 · utility

Assignee

• The Board of Regents of the University of Texas System · US

Inventors

• Connie Hsia · Dallas, US
• Yi Hong · Irving, US
• Orson W. Moe · Dallas, US
• Kytai NGUYEN · Grand Prairie, US

Key dates

• Filing date: Jul 8, 2016
• Grant date: Nov 8, 2022
• Expiry date: Jul 24, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Y302/01031
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Nanoparticles coated with extracellular matrix (ECM) are provided, in some aspects, for the delivery of a therapeutic protein, nucleic acid, or drug. In some embodiments, the nanoparticles are delivered to a subject via inhalation or aerosol delivery. Also provided, in some aspects, are methods for treating acute lung injury comprising administering α-Klotho (αKlotho) protein or DNA to a subject.