Article of manufacture comprising local anesthetic, buffer, and glycosaminoglycan in syringe with improved stability

US11491179B2 · kind B2 · utility

Assignee

• Urigen Pharmaceuticals, Inc. · US

Inventors

• Dan VICKERY · Adams, US
• Christopher P. Meenan · Lincoln Park, US
• Lowell C. Parsons · Henderson, US
• Andreas Meier · Wilhermsdorf, DE

Key dates

• Filing date: Apr 11, 2018
• Grant date: Nov 8, 2022
• Expiry date: Oct 20, 2038

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P31/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

An article of manufacture according to the present invention comprises a composition including a glycosaminoglycan, a local anesthetic, and a buffer packaged in a syringe or vial constructed from either glass or a plastic selected from the group consisting of cyclic olefin polymer, cyclic olefin copolymer, or high density non-nucleated polypropylene. The composition has unexpectedly improved stability on storage. The composition can be formulated for treatment of a urinary tract disease or condition, such as interstitial cystitis, also known as bladder pain syndrome or hypersensitive bladder syndrome.