Patent · US Active

Archaeal pyrrolysyl tRNA synthetases for orthogonal use

US11492608B2 · kind B2 · utility

0Cited by

2References

5Claims

0Family size

Assignee

European Molecular Biology Laboratory · DE

Inventors

Edward Lemke · Mannheim, DE
Ivana Nikic · Tübingen, DE
Gemma Estrada Girona · Heidelberg, DE
Christine KÖHLER · Forst, DE

Key dates

Filing date	Oct 13, 2017
Grant date	Nov 8, 2022
Priority date	—
Expiry date	Mar 23, 2039

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N15/11
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The invention relates to archaeal pyrrolysyl tRNA synthetases lacking a nuclear localization signal and/or comprising a nuclear export signal. The invention also relates to polynucleotides encoding said pyrrolysyl tRNA synthetases, eukaryotic cells comprising said polynucleotide and tRNA acylated by the pyrrolysyl tRNA synthetase or a polynucleotide encoding such tRNA, methods utilizing said cells for preparing polypeptides comprising unnatural amino acid residues, and kits useful in said methods.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.