3′-UTR sequences for stabilization of RNA

US11492628B2 · kind B2 · utility

Assignees

• BIONTECH SE · DE
• TRON—Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg-Universität Mainz · DE

Inventors

• Alexandra Orlandini Von Niessen · Mainz, DE
• Stephanie Fesser · Mainz, DE
• Britta Vallazza · Hagen, DE
• Tim Beissert · Groß-Gerau, DE
• Andreas Kuhn · Mainz, DE
• Ugur Sahin · Mainz, DE
• Marco Poleganov · Frankfurt, DE

Key dates

• Filing date: Oct 5, 2016
• Grant date: Nov 8, 2022
• Expiry date: Apr 21, 2038

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Furniture, games
• WIPO sector: Other fields

Abstract

The present invention relates to stabilization of RNA, in particular mRNA, and an increase in mRNA translation. The present invention particularly relates to a modification of RNA, in particular in vitro-transcribed RNA, resulting in increased transcript stability and/or translation efficiency. According to the invention, it was demonstrated that certain sequences in the 3′-untranslated region (UTR) of an RNA molecule improve stability and translation efficiency.