Patent · US Active

Composition and use of Cas protein inhibitors

US11492645B2 · kind B2 · utility

0Cited by

4References

13Claims

0Family size

Assignee

SHANGHAITECH UNIVERSITY · CN

Inventors

Jia Liu · Midland, US
Biao Jiang · Shanghai, CN
Peixiang Ma · Shanghai, CN
Guang Yang · Nanhu, CN

Key dates

Filing date	Aug 29, 2019
Grant date	Nov 8, 2022
Priority date	—
Expiry date	Aug 29, 2039

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2795/14143
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Provided are amino acid sequences capable of binding to and inhibiting a Cas protein's ability to bind to a nucleic acid molecule, thereby inhibiting the Cas protein's function in genome editing. Such Cas protein inhibitors, which can be comprised of a major coat protein (G8P), an extracellular region of the G8P (G8PEX), or a biological equivalent, are useful in improving the specificity of Cas protein-based genome editing procedures.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.