Event timing detection for DNA sequencing
US11493499B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Oct 30, 2018 |
| Grant date | Nov 8, 2022 |
| Priority date | — |
| Expiry date | Jul 14, 2041 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG16B30/00
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Systems and methods are disclosed for performing event timing detection for DNA sequencing. In certain embodiments, a method may comprise generating a signal based on a DNA strand passed through a nanopore sensor, sampling the signal to generate a plurality of sample values, and detecting one or more event boundaries based on the sample values, an event representing a movement of a single DNA base of the DNA strand through the nanopore sensor. Detecting the one or more event boundaries may include segmenting the plurality of sample values into multiple events to calculate an optimal total score, assigning an event value to a selected event from the multiple events based on sample values of the selected event, and providing the event value to a base caller to determine a sequence of DNA bases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.