Methods of characterizing condensate-associated characteristics of compounds and uses thereof

US11493519B2 · kind B2 · utility

Assignee

• Dewpoint Therapeutics, Inc. · US

Inventors

• Bruce Aaron BEUTEL · Needham, US
• Peter Jeffrey DANDLIKER · Quincy, US
• Stephen Hale · Belmont, US
• Mark A. Murcko · Holliston, US
• Edgar Erik BOCZEK · Dresden, DE
• Matthäus MITTASCH · Dresden, DE
• Diana Maria MITREA · Canton, US

Key dates

• Filing date: Feb 7, 2020
• Grant date: Nov 8, 2022
• Expiry date: Apr 15, 2041

Classification

• Technology area (CPC H): Electricity
• CPC primary: H01J49/26
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Methods of assessing, such as characterizing or determining, condensate-associated characteristics of a compound, such as a test compound, and applications thereof are provided. For example, methods of determining a partition characteristic of a test compound in a target condensate, methods of determining a relative partition characteristic of a test compound in a target condensate, and methods of determining a condensate preference profile of a test compound are provided. Additionally, methods of designing and/or identifying and/or making a compound, or portion thereof, with a desired relative condensate partition characteristic are provided.