Pyrimidine-fused cyclic compound, preparation method therefor and application thereof

US11498930B2 · kind B2 · utility

Assignee

• BLUERAY THERAPEUTICS (SHANGHAI) CO., LTD · CN

Inventors

• Bin Zou · Chandler, US
• Xianlei FU · Shanghai, CN
• Rui Zhang · Hubei, CN
• Shichao MA · Shanghai, CN
• Shuaijie Xu · Wuyi, CN
• Wencheng Fu · Shanghai, CN
• Lanzhen Liu · Shanghai, CN

Key dates

• Filing date: Feb 3, 2019
• Grant date: Nov 15, 2022
• Expiry date: Feb 14, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed in the present disclosure are a pyrimidine-fused cyclic compound or a pharmaceutically acceptable salt, hydrate, prodrug, stereoisomer, solvate or isotope labeled compound thereof. Also provided in the present disclosure are a preparation method for the compound, a composition comprising the compound and a use of the compound for the preparation of a medicament for the prevention and/or treatment of a disease or condition associated with abnormal SHP2 activity.