Multi-layered microfluidic systems for in vitro large-scale perfused capillary networks
US11499127B2 · kind B2 · utility
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Key dates
| Filing date | Oct 22, 2018 |
| Grant date | Nov 15, 2022 |
| Priority date | — |
| Expiry date | Oct 3, 2040 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12M23/58
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A multi-layered microfluidic system featuring tissue chambers for cells in a first layer and a plurality of medium channels for culture medium in a second layer. The tissue chambers fluidly connect to the medium channels such that media flows from the medium channels to the tissue chambers, forming large-scale perfused capillary networks. The capillary networks can undergo angiogenesis and vertical anastomosis. The multi-layered configuration of the system of the present invention allows for flexibility in design.
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