Patent · US Active

Adeno-associated virus (AAV) with modified phospholipase domain

US11499141B2 · kind B2 · utility

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20Claims

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Assignee

Benitec IP Holdings Inc. · US

Inventors

Vanessa Strings-Ufombah · Hayward, US
Shih-Chu Kao · Fawn Drive, AU
Petrus W. Roelvink · Campbell, US

Key dates

Filing date	Aug 30, 2018
Grant date	Nov 15, 2022
Priority date	—
Expiry date	Nov 16, 2039

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2750/14152
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The present disclosure relates generally to modified adeno-associated virus (AAV) from serotypes other than serotype 2, which have a viral capsid protein with a subunit 1 (VP1) sequence which is modified relative to the corresponding wildtype sequence. In particular, the modified AAVs of the disclosure comprise site-specific amino acid substitutions within the phospholipase A2 (PLA2) domain and flanking sequence relative to the corresponding wild-type sequence which improve functionality of the AAV when produced in insect cells. The present disclosure also relates to methods of producing the modified AAVs, reagents therefor, baculovirus expression systems and insect cells for producing said modified AAVs.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.