Transgenic plant with reduced fucosyltransferase and xylosyltransferase activity
US11499160B2 · kind B2 · utility
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Key dates
| Filing date | Nov 29, 2017 |
| Grant date | Nov 15, 2022 |
| Priority date | — |
| Expiry date | Nov 29, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y204/02038
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A genetically modified plant or plant cell with reduced α1,3-fucosyltransferase and β1,2-xylosyltransferase activity compared to a wild type plant or plant cell, wherein less than 10% of the total glycan on a protein produced by the plant or plant cell is α1,3-fucosylated glycan and less than 3% of the total glycan on the protein is β1,2-xylosylated glycan is provided. In one embodiment, the plant or plant cell comprises three T-DNA insertions expressing five copies of RNAi targeting α1,3-fucosyltranserase and three copies of RNAi targeting β1,2xylosyltransferase.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.