Method for preparing liposome comprising ultrasound reactive microbubble for drug delivery and liposome using same
US11504328B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Mar 20, 2019 |
| Grant date | Nov 22, 2022 |
| Priority date | — |
| Expiry date | Jun 11, 2039 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01F2101/22
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided are a method for preparing liposomes comprising ultrasound reactive microbubbles for drug delivery, comprising (a) a step of producing ultrasound reactive microbubbles comprising an inert gas therein and having a first shell formed on the outer surface thereof, followed by forming a uniform size distribution of the ultrasound reactive microbubbles through an extruder; and (b) a step of producing liposomes comprising the ultrasound reactive microbubbles distributed in a uniform size and a medicament therein and having a second shell formed on the outer surface thereof, followed by forming a uniform size distribution of the liposomes through an extruder; and a liposome using same.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.