Pharmaceutical compositions comprising (S)-2-(2,6-dioxopiperidin-3-yl)-4-((2-fluoro-4-((3-morpholinoazetidin-1-yl)methyl)benzyl)amino)isoindoline-1,3-dione and methods of using the same

US11504378B2 · kind B2 · utility

Assignee

• CELGENE CORPORATION · US

Inventors

• Sreenivas S. Bhat · Kendall Park, US
• Fabien Boulineau · Livingston, US
• Donna Carroll · Garwood, US
• Tracy Lee Gaebele · Green Brook, US
• Yuchuan Gong · Waukegan, US
• Isabel Minjung Hong · Summit, US
• Zhengmao Li · Livingston, US
• Ye Tian · Bloomington, US

Key dates

• Filing date: Oct 20, 2020
• Grant date: Nov 22, 2022
• Expiry date: Oct 20, 2040

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K47/42
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are pharmaceutical compositions (e.g., oral dosage formulations) comprising (S)-2-(2,6-dioxopiperidin-3-yl)-4-((2-fluoro-4-((3-morpholinoazetidin-1-yl)methyl)benzyl)amino)isoindoline-1,3-dione, or an enantiomer, mixture of enantiomers, tautomer, isotopolog, or pharmaceutically acceptable salt thereof, and a carrier or diluent. Also provided herein are methods of preparing and methods of using the pharmaceutical compositions.