Photosensitizer and derivatives and application thereof

US11504428B2 · kind B2 · utility

Assignees

• Dalian University of Technology · CN
• DALIAN CHROMAS BIOSCIENCE CO., LTD · CN

Inventors

• Xiaojun Peng · Dalian, CN
• Mingle Li · 东风镇, CN
• Jiangli Fan · 东风镇, CN
• Qichao YAO · 东风镇, CN
• Jianjun Du · Nanhu, CN
• Saran Long · 东风镇, CN
• Jingyun Wang · 东风镇, CN

Key dates

• Filing date: Nov 24, 2017
• Grant date: Nov 22, 2022
• Expiry date: Sep 2, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D495/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A photosensitizer and derivative, application thereof. The photosensitizer has the structure of general formula I, wherein X is S or Se, Y is organic or inorganic ion, R1 and R2 are independently selected from H, alkyl, alkoxy, alkyl amido, alkyl azide and the like; R3 is selected from H, alkyl, alkoxy, amino sulfonyl, hydroxyl, carboxyl and the like, and L1 is a linker selected from —(CH2)n1— or —(CH2CH2O)n2—. The derivatives are molecular medicines with drug molecules of anticancer and chemotherapy or tumor targeting function connected to the said photosensitizer. The photosensitizer has excellent near infrared characteristics and low dark toxicity and is used in the field of photodynamic tumor therapy. The introduction of benzophenothiazine or benzophenoselenazine into derivatives with tumor-targeting function could improve the specific uptake of photosensitizer in tumor tissues. Moreover, clinical anticancer drugs can be introduced into the structure of benzophenothiazine or benzophenoselenazine to achieve the purpose of combining therapy of photodynamic therapy and chemotherapy.