Preparation method for morpholinquinazoline compound and intermediates thereof
US11505542B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Dec 24, 2019 |
| Grant date | Nov 22, 2022 |
| Priority date | — |
| Expiry date | Dec 24, 2039 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D401/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present disclosure relates to a preparation method morpholinquinazoline compound and a midbody thereof. The preparation method for morpholinquinazoline compound comprises the following steps: S1, performing a Suzuki reaction of compound S and compound IV as represented by the following formula, so as to obtain compound V; step S2, performing a reaction of methylsufonyl chloride and compound V in an organic solvent as represented by the following formula, so as to obtain compound VI; and S3, performing a coupled reaction of compound VII and compound VI in a solvent as represented by the following formula, so as to obtain compound YY-20394. The preparation method has the advantages of higher yield, better selectivity, simple operation and mild reaction condition, and is applicable to industrial production.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.