Heterobifunctional compounds with improved specificity
US11505560B2 · kind B2 · utility
1Cited by
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16Claims
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Key dates
| Filing date | Oct 19, 2018 |
| Grant date | Nov 22, 2022 |
| Priority date | — |
| Expiry date | Oct 19, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D487/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed are heterobifunctional compounds that effectuate selective degradation of a target protein, and which include a targeting ligand that binds a target protein and at least one other protein, a ligand that binds an E3 ubiquitin ligase or a component of E3 ubiquitin ligase, and a specificity modulating linker that links the first ligand and the second ligand. Pharmaceutical compositions containing the compounds, and methods of using and making the compounds are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.