Method for improving aqueous solubility of water-insoluble or slightly water-soluble drugs
US11510859B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jul 15, 2016 |
| Grant date | Nov 29, 2022 |
| Priority date | — |
| Expiry date | Apr 13, 2038 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61Q19/005
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of increasing the solubility of a water-insoluble or slightly water-soluble hydrophobic organic compound in an aqueous solvent includes adding a saponin component selected from escin, glycyrrhizin, and Quillaya saponaria extract to the aqueous solvent in an amount sufficient to trigger the formation of micelles, wherein in a first step the hydrophobic organic compound is pre-dissolved in an organic solvent, and in a second step the organic solvent comprising the pre-dissolved compound is admixed to the aqueous solvent, whereby at least a part of the insoluble or slightly soluble hydrophobic organic compound gets solubilized and dissolved in the aqueous solvent, yielding an aqueous composition having an increased concentration of said organic compound dissolved therein. Also indicated are pharmaceutical or cosmetic compositions including a water-insoluble or slightly water-soluble organic compound dissolved in an aqueous solvent at substantially increased concentrations.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.