Pharmaceutical composition of apixaban

US11510909B2 · kind B2 · utility

Assignee

• Unichem Laboratories Ltd · IN

Inventors

• Dhananjay Govind Sathe · Mumbai, IN
• Srikant PIMPLE · Ashti, IN
• Pravin Kumar Maurya · Pune, IN
• Dhananjay Pramod Tattu · Ashti, IN
• Milind Vinayak SATHE · Ashti, IN

Key dates

• Filing date: Feb 1, 2018
• Grant date: Nov 29, 2022
• Expiry date: Feb 5, 2038

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/4545
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure relates to a stable, reproducible and bioequivalent apixaban compositions, wherein the composition comprising apixaban having a D90 particle size of more than 100 microns, preferably between 300 and 1000 microns, and more preferably between 350 and 800 microns, and further comprising one or more pharmaceutically acceptable excipients. The present disclosure further provides a process for preparation of a pharmaceutical composition comprising apixaban by wet granulation.