Process for preparation of amino alcohols

US11512040B2 · kind B2 · utility

Assignees

• BASF SE
• The Regents of the University of California · US

Inventors

• Martin Ernst · Ludwigshafen am Rhein, DE
• Stephan ZUEND · Hayward, US
• Bo Su · New Taipei, TW
• Ala Bunescu · Cambridge, GB
• John F. Hartwig · Durham, US

Key dates

• Filing date: Jul 2, 2019
• Grant date: Nov 29, 2022
• Expiry date: Oct 29, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C249/02
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process for the preparation of amino alcohols includes condensing a compound of Formula (II), a stereoisomer, a tautomer, or a salt thereof with a compound of Formula (IIIa) or Formula (IIIb), a stereoisomer, a tautomer, or a salt thereof to form a condensation product; hydroxylating or acyloxylating the condensation product in the presence of an oxidant to obtain a hydroxylation or acyloxylation product; and subjecting the hydroxylation or acyloxylation product to one or more subsequent reactions comprising a hydrolysis reaction, alcohol deprotection, an amino lysis reaction, or a combination of two or more thereof to obtain an amino alcohol of Formula (I).