Guanidyl-containing P2Y12 receptor antagonist and preparation method and application thereof

US11512056B2 · kind B2 · utility

Assignee

• Anhui New Star Pharmaceutical Development Co., Ltd · CN

Inventors

• Xiaoxiang Li · Hefei, CN
• Ziao Xu · Meekrap-oord, CN
• Degang Li · Hefei, CN
• Yumei Xu · Hefei, CN
• Yonghai Zhao · Hefei, CN
• Genling Jiang · Hefei, CN

Key dates

• Filing date: Nov 25, 2020
• Grant date: Nov 29, 2022
• Expiry date: Jan 26, 2041

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P7/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A P2Y12 receptor antagonist containing a guanidyl, and a preparation method and the use thereof. In particular, the present disclosure provides a pyridazinone-guanidine compound that is a compound of structural formula (I), or a stereoisomer of the above-mentioned compound, a pro-drug thereof, a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable solvate thereof. Such a compound has multiple pharmacological activities, especially has an inhibitory effect on platelet aggregation, and can be used for preparing an anti-platelet aggregation pharmaceutical composition.