Patent · US Active

Aminocyclobutanes as monoacylglycerol lipase modulators

US11512059B2 · kind B2 · utility

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16Claims

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Assignee

Janssen Pharmaceuticals, Inc. · BE

Inventors

Michael K. Ameriks · San Diego, US
Pablo Garcia-Reynaga · San Diego, US

Key dates

Filing date	Mar 25, 2021
Grant date	Nov 29, 2022
Priority date	—
Expiry date	Mar 25, 2041

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P35/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Aminocyclobutane compounds of Formula (I), and pharmaceutically acceptable salts, isotopes, N-oxides, solvates, and stereoisomers thereof, pharmaceutical compositions containing them, and methods of using them including methods for treating disease states, disorders, and conditions associated with MGL modulation, such as those associated with pain, psychiatric disorders, neurological disorders (including, but not limited to major depressive disorder, treatment resistant depression, anxious depression, autism spectrum disorders, Asperger syndrome, bipolar disorder), cancers and eye conditions: wherein X, R1, R2a, R2b, R3 and R4 are defined herein.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.