Modified microcystins and nodularins

US11512114B2 · kind B2 · utility

Assignee

• Cyano Biotech GmbH · DE

Inventors

• Heike Enke · Berlin, DE
• Wolfram Lorenzen · Berlin, DE
• Stefan Jahns · Berlin, DE
• Dan Enke · Berlin, DE
• Timo Niedermeyer · Halle (Saale), DE
• Julia Moschny · Sulzbach-Rosenberg, DE

Key dates

• Filing date: May 9, 2018
• Grant date: Nov 29, 2022
• Expiry date: May 9, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A compound includes cytotoxic agents such as microcystin and nodularin. More specifically, a modified microcystin and/or nodularin compound contains one or more modified substrates, wherein one or more modified substrates include an anchor group directly accessible or transformable for use in conjugation chemistry (incl. click chemistry), for the attachment of a targeting moiety. This compound is useful for cancer treatment.