Compositions and methods for making antibodies based on use of an expression-enhancing loci
US11512144B2 · kind B2 · utility
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43Claims
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Key dates
| Filing date | Apr 20, 2017 |
| Grant date | Nov 29, 2022 |
| Priority date | — |
| Expiry date | Jul 29, 2039 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N15/907
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
This invention relates to site-specific integration and expression of recombinant proteins in eukaryotic cells. In particular, the invention includes compositions and methods for improved expression of antigen-binding proteins including monospecific and bispecifc antibodies in eukaryotic cells, particularly Chinese hamster (Cricetulus griseus) cell lines, by employing multiple expression-enhancing locus.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.