Methods and systems for 3D structure estimation
US11515002B2 · kind B2 · utility
Inventors
Key dates
| Filing date | Feb 28, 2019 |
| Grant date | Nov 29, 2022 |
| Priority date | — |
| Expiry date | Oct 1, 2041 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG16B15/00
- WIPO fieldComputer technology
- WIPO sectorElectrical engineering
Abstract
Disclosed herein are systems and methods for efficient 3D structure estimation from images of a transmissive object, including cryo-EM images. The method generally comprises, receiving a set of 2D images of a target specimen from an electron microscope, carrying out a reconstruction technique to determine a likely molecular structure, and outputting the estimated 3D structure of the specimen. The described reconstruction technique comprises: establishing a probabilistic model of the target structure; optimizing using stochastic optimization to determine which structure is most likely; and, optionally utilizing importance sampling to minimize computational burden.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.