Liver support system devices and methods thereof

US11517855B2 · kind B2 · utility

Assignee

• GAMBRO LUNDIA AB · SE

Inventors

• Ralf Flieg · Rangendingen, DE
• Bernd Krause · Liederbach, DE
• Markus Storr · Echterdingen, DE

Key dates

• Filing date: Sep 5, 2017
• Grant date: Dec 6, 2022
• Expiry date: Oct 3, 2039

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B01D2325/20
• WIPO field: Chemical engineering
• WIPO sector: Chemistry

Abstract

The present disclosure relates to an artificial, extracorporeal system for supporting the function of the liver of a patient suffering from liver failure, which is characterized in that it comprises a first high-flux or high cut-off hollow fiber membrane dialyzer which is perfused on the lumen side with the patient's blood and wherein a buffered aqueous solution comprising human serum albumin is passed in a continuous flow through the filtrate space of said first dialyzer, a second hollow fiber membrane dialyzer which removes water-soluble substances from the dialysate of said first dialyzer, and a third, integrated hollow fiber membrane dialyzer which is perfused with the retentate of second hemodialyzer and which allows the passage of certain amounts of albumin over the membrane wall into the filtrate space which is populated with adsorbent material. The system can be used for the treatment of acute liver failure and acute-on-chronic liver failure.