Compositions and methods of cell attachment
US11519903B2 · kind B2 · utility
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16Claims
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Key dates
| Filing date | Jul 12, 2017 |
| Grant date | Dec 6, 2022 |
| Priority date | — |
| Expiry date | Jul 12, 2037 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/5044
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Compositions, devices and methods are described for improving adhesion, attachment, and/or differentiation of cells in a microfluidic device or chip. In one embodiment, one or more ECM proteins are covalently coupled to the surface of a microchannel of a microfluidic device. The microfluidic devices can be stored or used immediately for culture and/or support of living cells such as mammalian cells, and/or for simulating a function of a tissue, e.g., a liver tissue, muscle tissue, etc. Extended adhesion and viability with sustained function over time is observed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.