Prodrugs of alpha-ketoglutarate, alpha-ketobutyrate, alpha-ketoisovalerate, and alpha-ketoisohexanoate, and uses thereof

US11524948B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Michael E. Jung · Los Angeles, US
• Jing Huang · New Taipei, TW
• Yanpeng Xing · Los Angeles, US
• Brett E. Lomenick · Los Angeles, US
• Min Chai · Los Angeles, US
• Xudong Fu · Los Angeles, US

Key dates

• Filing date: Jun 30, 2020
• Grant date: Dec 13, 2022
• Expiry date: Jun 30, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/113
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides compounds of Formula (VIA), Formula (IIIA), Formula (IVA), and Formula (VA). The compounds are prodrugs of alpha-ketoglutarate, alpha-ketobutryrate, alpha-ketoisovalerate, and alpha-ketoisohexanoate, which are useful in treating or preventing age related diseases, disorders, or conditions.