Anti-betacellulin antibodies, fragments thereof, and multi-specific binding molecules

US11524998B2 · kind B2 · utility

Assignee

• Novartis AG · CH

Inventors

• Chad Bigelow · Cambridge, US
• Ana Maria CARRION · Wellesley, US
• James Edgar CHASTAIN · Acton, US
• Kirk Lee CLARK · Stow, US
• Bijan Etemad-Gilbertson · Brookline, US
• Joy Ghosh · Boston, US
• Shawn Michael HANKS · Sudbury, US
• Nicole HAUBST · Munich, DE
• Ganesh Rajan IYER · Grafton, US
• Nina Moker · Cologne, DE
• Andrew Anh NGUYEN · Brookline, US
• Stephen Hedrick Poor · Winthrop, US
• Yubin Qiu · Newton, US
• Nalini Velamur RANGASWAMY · Wakefield, US
• Michael Stefanidakis · Brookline, US
• Engin Toksoz · Munich, DE
• Michael Zbigniew TWAROG · Cambridge, US

Key dates

• Filing date: Jul 14, 2021
• Grant date: Dec 13, 2022
• Expiry date: Jul 14, 2041

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/92
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides anti-BTC antibodies, methods of producing said antibodies, pharmaceutical compositions comprising said antibodies, and methods of using said antibodies. The present disclosure also provides multi-specific binding molecules, e.g., bispecific antibodies, comprising a BTC binding moiety and an anti-VEGF binding moiety.