Chimeric proteins

US11525133B2 · kind B2 · utility

Assignee

• Cambridge Enterprise Limited · GB

Inventors

• Laura Itzhaki · Cambridge, GB
• Alberto Perez Riba · Cambridge, GB
• Pamela Rowling · Cambridge, GB
• Grasilda Zenkevi{hacek over (c)}iüte · Cambridge, GB

Key dates

• Filing date: May 31, 2019
• Grant date: Dec 13, 2022
• Expiry date: Dec 31, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2318/20
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention relates to modular proteins that interact with one or more target molecules. The chimeric proteins comprise two or more repeat domains, such as tetratricopeptide repeat domains; inter-repeat loops linking the repeat domains; and one or more peptide ligands. Each peptide ligand is located in an inter-repeat loop or at the N or C terminus of the chimeric protein. The peptide ligands may include heterologous peptidyl binding motifs, such as short linear motifs (SLiMs). Chimeric proteins with various configurations and methods for their production and use are provided.