Method of preparing silica nanocapsules and silica nanocapsules
US11529317B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Mar 28, 2018 |
| Grant date | Dec 20, 2022 |
| Priority date | — |
| Expiry date | Sep 25, 2038 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2800/651
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
There is provided a method of preparing silica nanocapsules, the method comprising mixing a surfactant with water at a temperature that is above the gel-to-liquid transition temperature of the surfactant to form a mixture, passing the mixture one or more times through at least one pore to obtain a dispersion of vesicles, and adding a silica precursor to the dispersion of vesicles to form silica nanocapsules. Also provided is a silica nanocapsule formed from a vesicle template, and a method of delivering one or more types of molecules to a subject. In a specific embodiment, hollow silica nanocapsules having substantially lens-shaped are synthesized by employing dimethyldioctadecylammonium bromide (DODAB) or dioctadecyldimethyl ammonium chloride (DODAC) as the vesicle template and tetraethyl orthosilicate (TEOS) as the silica precursor.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.