Doubly attenuated late liver stage malaria parasites and related compositions and methods
US11529404B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 1, 2021 |
| Grant date | Dec 20, 2022 |
| Priority date | — |
| Expiry date | Feb 1, 2041 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The disclosure relates to doubly attenuated malaria parasites that have had the functionality of LISP2 and PlasMei2 genes interrupted through genetic manipulation. The double attenuated malaria parasites disclosed herein are useful for methods and compositions for stimulating of vertebrate host immune systems because of the complete cessation of lifecycle progression in the late liver stage, while providing a comprehensive antigenic presentation representing wildtype liver stage parasites. The disclosure also relates to the additional blood stage and gametocyte antigens to compositions of genetically attenuated malaria parasites (GAPs) to enhance efficient immune stimulation and prevention of disease and transmission related to the presence of blood stage parasites.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.