Virus and antigen purification and conjugation

US11529413B2 · kind B2 · utility

Assignee

• KBIO HOLDINGS LIMITED · GB

Inventors

• Leigh Burden · Owensboro, US
• Steven D. Hume · Owensboro, US
• Joshua D. Morton · Evansville, US
• Greg Pogue · Austin, US
• Barry Bratcher · Owensboro, US
• Hugh A. Haydon · Louisville, US
• Carrie A. Simpson · Evansville, US
• Nick Partain · Owensboro, US
• John W. Shepherd · Owensboro, US

Key dates

• Filing date: Dec 10, 2019
• Grant date: Dec 20, 2022
• Expiry date: Sep 15, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2770/40051
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein are methods of forming compounds and exemplary compounds in the nature of a conjugated compound demonstrating enhanced stability, which in some embodiments comprises a protein and virus particle mixed in a conjugation reaction to form a conjugate mixture, such that the conditions and steps of forming these products allow for unrefrigerated storage for longer time periods than previous approaches, thus making feasible access to such products over a global supply chain.