Patent · US Active

Dynamic control of colocalization of proteins

US11530278B2 · kind B2 · utility

0Cited by

0References

20Claims

0Family size

Assignee

University Of Delaware · US

Inventors

Wilfred Chen · Hockessin, US
Alexander A. Mitkas · Nonatum Mills, US

Key dates

Filing date	Jan 24, 2020
Grant date	Dec 20, 2022
Priority date	—
Expiry date	Feb 29, 2040

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2310/531
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The present invention provides a method for controlling colocalization of two or more proteins in a cell. The method comprises expressing the proteins, scaffold RNA molecules having binding motifs for the proteins, and a trigger RNA molecule in the cell. In the presence of the trigger RNA molecule, a scaffold may be assembled (ON) by the scaffold RNA molecules via hybridization such that the proteins may be colocalized; or disassembled (OFF) such that the proteins may be separated and not colocalized. The proteins may provide a biological activity when colocalized or not colocalized.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.