Cationic polymers with D-fructose substituents

US11530296B2 · kind B2 · utility

Assignee

• Friedrich-Schiller-Universitat Jena · DE

Inventors

• Michael GOTTSCHALDT · Jena, DE
• Michael Proehl · Jena, DE
• Christoph Englert · Alexandria, US
• Ulrich Schubert · Jena, DE

Key dates

• Filing date: Mar 23, 2018
• Grant date: Dec 20, 2022
• Expiry date: Jan 13, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08G73/0226
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to new cationic polymers conjugated with D-fructose, as a result of which they can selectively interact with specific structure elements on cell surfaces. The problem was that of creating novel, biocompatible, easy-to-produce, D-fructose-conjugated cationic polymers that have a higher selectivity with respect to certain cell types. To solve this problem, the invention proposes cationic polymers with covalently bonded D-fructose of general formula (I) with the following components: a) cationic polymer: macromolecular compounds of n repeat units with one or more positive charges; b) linker: a unit that links the cationic polymer with D-fructose or derivatives of D-fructose by means of any alkyl or aryl group, any alkenyl or alkinyl group, an ether, thioether or amine, an ester, amide or other carboxylic acid derivative, a heterocycle (e.g. triazole or m maleimide), a disulphide, an imine or an imide; c) D-fructose: one or more D-fructoses or D-fructose derivatives in an open-chain, furanoid or pyranoid structure, not glycosidically linked via one of the five possible carbon atoms (1, 3, 4, 5, 6).