Patent · US Active

Methods of engineering human induced pluripotent stem cells to produce liver tissue

US11530388B2 · kind B2 · utility

0Cited by

1References

40Claims

0Family size

Assignee

University of Pittsburgh—Of the Commonwealth System of Higher Education · US

Inventors

Alejandro Soto-Gutierrez · Pittsburgh, US
Tomoji MASHIMO · Kyoto, JP
Alexandra Sylvie Collin de l'Hortet · Pittsburgh, US
Eduardo Cervantes Alvarez · Huixquilucan de Degollado, MX
Jorge Guzman Lepe · Pittsburgh, US
Kan Handa · Pittsburgh, US
Kazuki Takeishi · Pittsburgh, US
Yang Wang · Kingston, CA
Branimir Popovic · Pittsburgh, US

Key dates

Filing date	Feb 13, 2018
Grant date	Dec 20, 2022
Priority date	—
Expiry date	Apr 2, 2039

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2506/45
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

Methods are disclosed herein for producing human hepatocytes from human induced pluripotent stem cells. Also provided are transgenic rats for the expansion of human hepatocytes, such as those produced using the methods disclosed herein.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.