Distinguishing protein aggregation mechanisms
US11532381B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Jan 12, 2017 |
| Grant date | Dec 20, 2022 |
| Priority date | — |
| Expiry date | Apr 21, 2040 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2015/0092
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Method, device, and system for identifying a model-based time dependent light scattering signature that includes receiving an experimental time dependent light scattering signature comprising experimental data descriptive of an average molecular weight of protein components in a solution over time. The method further includes identifying an Ansatz for evaluating the experimental time dependent light scattering signature, the Ansatz being an initial model-based time dependent light scattering signature, the initial model-based time dependent light scattering signature identifying at least one key variable. The method also includes adjusting the at least one key variable in the initial model-based time dependent light scattering signature until a final model-based time dependent light scattering signature is identified. In some instances, the final model-based time dependent light scattering signature identifies at least one protein aggregation mechanism.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.