Porous implantable devices

US11534283B2 · kind B2 · utility

Assignees

• CHILDREN'S NATIONAL MEDICAL CENTER · US
• UNIVERSITY OF MARYLAND, COLLEGE PARK · US

Inventors

• Alexander I. Son · Washington, US
• Kazue Hashimoto-Torii · Bethesda, US
• Masaaki Torii · Bethesda, US
• Paul D. Morton · Silver Spring, US
• Seiji Ishii · Yokohama, JP
• Justin Opfermann · Washington, US
• Judy Liu · Claremont, US
• John Fisher · Boise, US
• Marco Santoro · Silver Spring, US
• Peter Kim · Washington, US

Key dates

• Filing date: Sep 6, 2018
• Grant date: Dec 27, 2022
• Expiry date: Aug 16, 2039

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2300/258
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Porous implantable devices for housing one or more therapeutic agents are disclosed herein. The implantable devices include a porous outer wall defining an interia or void. The interior void houses a carrier material carrying a first therapeutic agent. The implantable devices are made by patterning at least a portion of a polymerizable substrate into a polymerized three-dimensional porous outer wall surrounding an interior void. This can be achieved by two-photon polymerization techniques. A first therapeutic agent is then added to the interior void, which is then sealed. Methods of treating diseases using the implantable devices are disclosed herein. The methods include implanting the implantable device at a target area and locally releasing a therapeutically effective dosage of a first therapeutic agent from the interior void. The implantable devices can also be used in methods of screening potentially therapeutic agents for desired biological responses.