Enhanced expression of RNA vectors
US11534417B2 · kind B2 · utility
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20Claims
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Key dates
| Filing date | Sep 5, 2018 |
| Grant date | Dec 27, 2022 |
| Priority date | — |
| Expiry date | Jun 28, 2041 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to methods and compositions for enhancing expression from RNA expression vectores. The invention is based upon the observation that reducing the frequency of the dinucleotide CpG and UpA has a significant effect on expression from such vectores. Aspects of the invention include, amongst others, synthetic RNA vectores, virions, cells, methods of producing vaccines and methods of treatment or immunisation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.