Formulation and method of synthesis
US11534494B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Aug 19, 2020 |
| Grant date | Dec 27, 2022 |
| Priority date | — |
| Expiry date | Oct 4, 2040 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07B59/001
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides a novel method for the preparation of 18F-fluoride (18F) for use in radiofluorination reactions. The method of the invention finds use especially in the preparation of 18F-labelled positron emission tomography (PET) tracers. The method of the invention is particularly advantageous where bulk solutions are prepared and stored in prefilled vials rather than being freshly prepared on the day of synthesis. Also provided by the present invention is a radiofluorination reaction which comprises the method of the invention, as well as a cassette for use in carrying out the method of the invention and/or the radiofluorination method of the invention on an automated radiosynthesis apparatus.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.