Tissue factor-targeted antibody-drug conjugate

US11534495B2 · kind B2 · utility

Assignees

• FUDAN UNIVERSITY · CN
• SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES · CN
• SHANGHAI MIRACOGEN INC. · CN

Inventors

• Ke Yu · Alpharetta, US
• Jingkang Shen · Shanghai, CN
• Tao Meng · North Plainfield, US
• Lanping Ma · Shanghai, CN
• Xuesai Zhang · Shanghai, CN
• Qingrou Li · Shanghai, CN
• Qing Lin · San Diego, US

Key dates

• Filing date: Jun 9, 2017
• Grant date: Dec 27, 2022
• Expiry date: Jul 21, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/90
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A tissue factor (TF)-targeted antibody-drug conjugate (ADC) and a method for preparing the ADC. The ADC is capable of binding to TF antigen with high specificity, and has high affinity, low immunogenicity, high cytotoxicity, and significant anti-tumor activity.