Patent · US Active

Sterilization of self-assembling peptides by irradiation

US11534528B2 · kind B2 · utility

2Cited by

6References

12Claims

0Family size

Assignee

3-D Matrix, Ltd. · JP

Inventors

Marika G. Rioult · Cambridge, US
Eun Seok Gil · Acton, US
Elton Aleksi · Riverdale, US
Naoki Yamamoto · Chita, JP

Key dates

Filing date	Mar 30, 2021
Grant date	Dec 27, 2022
Priority date	—
Expiry date	Mar 30, 2041

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K38/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Gamma ray and e-beam irradiation provided efficient sterilization of certain self-assembling peptides (including RADA16 in solution) without substantial degradation of the major peptide, while, e.g., another self-assembly peptide, QLEL12 was significantly degraded following irradiation. Irradiation sterilization enhances the rheological property of, for example, RADA16 hydrogel once applied to tissue at a physiological pH. The rheological property increase can result in higher efficacy in a variety of biomedical applications.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.