Multi-valent hepatitis B virus antigen binding molecules and uses thereof

US11535664B2 · kind B2 · utility

Assignee

• IGM Biosciences, Inc. · US

Inventors

• Stephen F. Carroll · Walnut Creek, US
• Ramesh Baliga · Redwood City, US
• Dean Ng · San Francisco, US
• Bruce Keyt · Pacifica, US

Key dates

• Filing date: Feb 19, 2020
• Grant date: Dec 27, 2022
• Expiry date: Feb 19, 2040

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2500/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This disclosure provides a multimeric hepatitis B virus (HBV) protein binding molecule, e.g., a dimeric IgA or a pentameric or hexameric IgM binding molecule, comprising at least two bivalent binding units, or variants or fragments thereof, each comprising at least two antibody heavy chain constant regions or fragments thereof, wherein each heavy chain constant region or fragment thereof is associated with an HBV antigen binding domain. The disclosure also provides compositions comprising the multimeric binding molecules, polynucleotides encoding the multimeric binding molecules, and methods to make and use the multimeric binding molecules.