Protein structure-based protein language models
US11538555B1 · kind B1 · utility
Assignees
Inventors
Key dates
| Filing date | Nov 22, 2021 |
| Grant date | Dec 27, 2022 |
| Priority date | — |
| Expiry date | Nov 22, 2041 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG16H50/20
- WIPO fieldComputer technology
- WIPO sectorElectrical engineering
Abstract
The technology disclosed relates to determining pathogenicity of nucleotide variants. In particular, the technology disclosed relates to specifying a particular amino acid at a particular position in a protein as a gap amino acid, and specifying remaining amino acids at remaining positions in the protein as non-gap amino acids. The technology disclosed further relates to generating a gapped spatial representation of the protein that includes spatial configurations of the non-gap amino acids, and excludes a spatial configuration of the gap amino acid, and determining a pathogenicity of a nucleotide variant based at least in part on the gapped spatial representation, and a representation of an alternate amino acid created by the nucleotide variant at the particular position.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.