Machine learning enabled pulse and base calling for sequencing devices
US11538556B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jan 25, 2019 |
| Grant date | Dec 27, 2022 |
| Priority date | — |
| Expiry date | Oct 29, 2041 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG16B40/30
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method includes obtaining, from one or more sequencing devices, raw data detected from luminescent labels associated with nucleotides during nucleotide incorporation events; and processing the raw data to perform a comparison of base calls produced by a learning enabled, automatic base calling module of the one or more sequencing devices with actual values associated with the raw data, wherein the base calls identify one or more individual nucleotides from the raw data. Based on the comparison, an update to the learning enabled, automatic base calling module is created using at least some of the obtained raw data, and the update is made available to the one or more sequencing devices.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.