Patent · US Active

Systems and methods for nucleic acid expression in vivo

US11541130B2 · kind B2 · utility

0Cited by

12References

10Claims

0Family size

Assignee

DNARx

Inventors

Robert James Debs · Mill Valley, US
Timothy D. Heath · Madison, US
Chakkrapong Handumrongkul · Richmond, US

Key dates

Filing date	Mar 23, 2018
Grant date	Jan 3, 2023
Priority date	—
Expiry date	Mar 3, 2041

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2310/20
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention provides compositions, systems, kits, and methods for expression of one or more biomolecules in a subject, human or non-human mammal, (e.g., at therapeutic levels for the extended periods of time required to produce therapeutic effects). In certain embodiments, compositions, systems, kits, and methods are provided that comprise a first composition comprising polycationic structures (e.g., empty cationic liposomes, cationic micelles, cationic emulsions, or cationic polymers) and a second composition comprising expression vectors (e.g., non-viral expression vectors not associated with liposomes or other carriers) encoding one or more biomolecules of interest.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.