Method of converting delta9-THC to delta10-THC and the purification of the delta10-THC by crystallization
US11542243B1 · kind B1 · utility
Inventors
Key dates
| Filing date | Sep 28, 2020 |
| Grant date | Jan 3, 2023 |
| Priority date | — |
| Expiry date | Jul 3, 2041 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2030/027
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
A method of isomerizing Δ9-tetrahydrocannabinol (“Δ9-THC”) to Δ10-tetrahydrocannabinol (“Δ10-THC”). The method includes the steps of: extracting Δ9-THC from cannabis biomass, which optionally contains one or more of the components found in fire retardant such as PHOS-CHEK®; dewaxing of crude extracts by winterization; pH-adjusting extracts by washing the extracts in heptane solution with aqueous solutions of: citric acid, sodium bicarbonate, and brine; isomerizing Δ9-THC to Δ10-THC by exposure to suitable conditions and in the presence of a catalyst based on the components of fire retardant; vacuum distillation of Δ10-THC at a predetermined temperature range and vacuum level; collecting the distillate and redistilling it up to three times to acquire distillate containing less than 60% Δ10-THC; and purification of the MO-THC to a purity of 99% or greater by crystallization from n-pentane solution.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.