Patent · US Active

Preparative process

US11542245B2 · kind B2 · utility

0Cited by

4References

17Claims

0Family size

Assignee

Bayer Pharma Aktiengesellschaft · DE

Inventors

Julian EGGER · Remscheid, DE
Daniel Goetz · Dressendorf, DE
Michal SOWA · Wuppertal, DE

Key dates

Filing date	Mar 8, 2019
Grant date	Jan 3, 2023
Priority date	—
Expiry date	May 17, 2039

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D401/10
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The present invention relates to a process for preparing 4-{[(2S)-2-{4-[5-chloro-2-(4-chloro-1H-1,2,3-triazol-1-yl)phenyl]-5-methoxy-2-oxopyridin-1(2H)-yl}butanoyl]amino}-2-fluorobenzamide (I) or 4-({(2S)-2-[4-{5-chloro-2-[4-(trifluoromethyl)-1H-1,2,3-triazol-1-yl]phenyl}-5-methoxy-2-oxopyridin-1(2H)-yl]butanoyl}amino)-2-fluorobenzamide (II) from 2,5-dimethoxypyridine (III), 1-(2-bromo-4-chlorophenyl)-4-chloro-1H-1,2,3-triazole (X-Cl) or 1-(2-bromo-4-chlorophenyl)-4-(trifluoromethyl)-1H-1,2,3-triazole (X-CF3), 4-amino-2-fluorbenzamide (XIII) and (2R)-2-aminobutanoic acid (XVII).

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.