Sting modulator compounds, and methods of making and using

US11542293B2 · kind B2 · utility

Assignee

• Takeda Pharmaceutical Company Limited · JP

Inventors

• Stepan Vyskocil · Arlington, US
• Jeffrey P. Ciavarri · Reading, US
• Courtney A. Cullis · Bedford, US
• Dylan Bradley ENGLAND · Cambridge, US
• Alexandra E. Gould · Cambridge, US
• Paul Greenspan · New Providence, US
• Yongbo Hu · Winchester, US
• Steven P. Langston · North Andover, US
• Gang Li · Beijing, CN
• Hirotake Mizutani · Cambridge, US
• Masanori Okaniwa · Osaka, JP

Key dates

• Filing date: Nov 9, 2018
• Grant date: Jan 3, 2023
• Expiry date: Dec 12, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H21/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present disclosure provides STING modulators/agonists, and methods of synthesis and methods for using for the prophylaxis or treatment of cancer and other STING-related diseases. The present disclosure relates to a compound represented by the Formula (I): wherein each symbol is as defined in the description, or a pharmaceutically acceptable salt thereof.