Patent · US Active

Synthetic protein circuits detecting signal transducer activity

US11542305B2 · kind B2 · utility

1Cited by

8References

22Claims

0Family size

Assignee

CALIFORNIA INSTITUTE OF TECHNOLOGY · US

Inventors

Xiaojing Gao · Pasadena, US
Michael B. Elowitz · Los Angeles, US

Key dates

Filing date	Aug 29, 2019
Grant date	Jan 3, 2023
Priority date	—
Expiry date	Sep 9, 2040

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2319/50
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

Disclosed herein include methods, compositions, and kits suitable for use in detecting the activation level of a signal transducer. In some embodiments, there are provided synthetic protein circuits wherein recruitment of synthetic protein circuit components to an association location upon activation of a signal transducer generates an active effector protein. The effector protein can be configured to carry out a variety of functions when in an active state, such as, for example, inducing cell death. Methods of treating a disease or disorder characterized by aberrant signaling are provided in some embodiments.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.