Patent · US Active

Method for producing 1,3-propanediol by fermentation of a recombinant microorganism

US11542533B2 · kind B2 · utility

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8Claims

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Assignee

TSINGHUA UNIVERSITY · CN

Inventors

Zhen Chen
Dehua Liu · Beijing, CN

Key dates

Filing date	Jul 17, 2018
Grant date	Jan 3, 2023
Priority date	—
Expiry date	Dec 16, 2038

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Y604/01002
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

Provided is a method for producing 1,3-propanediol by means of fermentation of a recombinant microorganism. First, a recombinant microorganism is provided; the recombinant microorganism can overexpress acetyl-CoA carboxylase genes: accBC and accDA, a malonyl-CoA synthetase gene: mcr, a 3-hydroxypropionyl-CoA synthetase gene: pcs, a 3-hydroxypropionyl-CoA reductase gene: pduP, and a 1,3-propanediol reductase gene: yqhD. The recombinant microorganism is subjected to fermentation culture in a flask or fermentor using glucose ad as raw material to obtain the 1,3-propanediol. The recombinant microorganism can utilize low-cost glucose, sucrose, molasses, xylose and the like as raw material in the fermentation process, without additional expensive vitamin B12. Thus, cost of the production is significantly reduced, and there is a promising prospect in market.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.